Studies of Tubercle Bacillus-histiocyte Relationships

Studies of Tubercle Bacillus-histiocyte Relationships* Vii. Homologous and Heterologous Transi~er of Cellular Resistance

A form of cellular resistance which has been intensively investigated in our laboratories is one that is directed against Mycobacterium tuberculosis. This cellular resistance, which is readily demonstrated with the histiocytes of rabbits immunized with the BCG strain of tubercle bacillus, is expressed in a number of ways depending upon the conditions of experimentation; one expression of this r...

STUDIES ON TUBERCLE BACILLUS-MONOCYTE RELATIONSHIP* II. INDUCTION O~ MONOCYTE DEGENERATION BY BACTERIA AND CULTu_V,E F~TRATE: SPECIFICITY 0]~ SERUM AND MONOCYTE EIIECTS ON P~ESISTANCE TO DEGENERATION

Studies of acquired immunity have revolved around the relative importance of humoral and cellular factors. As previously indicated (1), valid conclusions concerning the role of cells in acquired immunity against tuberculosis require analyses of bacterium-cell relationships during periods when the in dtro cell populations show no change in cell numbers. Under such conditions, it was observed tha...

Studies on Tubercle Bacillus-histiocyte Relationship

Studies of passive transfer of cellular resistance, as manifested by refractoriness to necrotization with virulent tubercle bacilli, have shown that immune histiocytes or immune lymphocytes were effective transferring agents; immune polymorphonuclear leucocytes and immune serum as well as comparable cells from normal animals lacked this capacity. Comparisons of immune histiocytes and immune lym...

Further Studies on the Survival Time of the Bovine Tubercle Bacillus in Soil, Soil and Dung, in Dung and on Grass, with Experiments on Feeding Guinea-pigs and Calves on Grass Artificially Infected with Bovine Tubercle Bacilli.

The Influence of Certain Organic Substances on the Growth of the Tubercle Bacillus

The power of a large number of aniline dyes to restrain the growth of Bacillus tuberculosis and Bacillus typhosus has been determined. Many substances have been found with especial restraining power for the tubercle bacillus under the conditions of the test. This capacity to restrain growth in the case of the tubercle bacillus apparently bears no simple relation to true disinfectant action. Opi...